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Title   병기 IIIb 자궁경부암의 방사선 - 온열 병용치료 결과 - 국소 관해율 , 생존율 및 예후인자 분석 - ( Results of Radio - thermotherapy in Stage IIIb Uterine Cervical Cancer - Local response , Survival rate and analysis of prognostic factor - )
Publicationinfo   2000 Jan; 032(04): 714-724.
Key_word   Cervix neoplasm, Stage IIlb, Radio - thermotherapy, Survival, Prognostic factor
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Abstract   Purpose: This retrospective study was conducted to obtain local response and survival rates, and to analyze prognostic factors affecting survival of patients treated with radio-thermotherapy for stage IIIb uterine cervical cancer. Materials and Methods: From May 1992 to Dec. 1996, 24 patients treated with radio-thermotherapy for stage IIIb uterine cervical cancer at department of Radiation Oncology in Kosin Medical College, Kosin University were enrolled. Radiotherapy used 6-10 MV linear accelerator was performed in whole pelvis with 4 portals box technique by conventional (180-200 cGy/ fraction, 5 fraction/week) method in 5 patients (20.8%) or hyperfractionated (120-135 cGy/fr., 2 fr./day, 10 fr./wk) in 19 patients (79.2%). Total dose of A-point was 67-112 Gy (median: 77.27 Gy). Hyperthermia used 8 MHz radiofrequency capacitive heating device was applied in pelvic area with 2-3 sessions per wk. Each course started within 15 to 20 minutes after radio- therapy and took 40 to 60 minutes. Local progression free (LPFS), disease free (DFS) and overall (OS) rates were calculated in survival analysis. Statistics was calculated by Kaplan-Meier Method in survival and Log-rank test in statistical significance. Multivariate analysis for prognostic factor was applied to Cox Regression model. Follow-up duration was 6-82 months (median: 25 months). Results: Overall local response rate was 95.S% (45.8% in CR/50.0% in PR). Five year LPFS, DFS, OS were 48.6%, 31.7%, 67.1%, respectively. In univariate analysis, an age was the significant prognostic factor in terms of OS (p=0.03), but was insignificant in LPFS and DFS. In multivariate analysis, none of evaluated factors are important in LPFS, DFS or OS. Conclusion: Radio-thermotherapy for stage IIIb uterine cervical cancer did not increase 5 year LPFS, DFS and OS in spite of higher local response rate. Age was the only significant factor for OS in univariate analysis.
저 자   문창우(Chang Woo Moon)